منابع مشابه
Screening of microbial extracts for tyrosine kinase inhibitors
riasis6'7). This has led to the general concept that PTK inhibition may combat hyperproliferative conditions which result from enhanced activity of PTKs8'9). Several synthetic inhibitors of PTKshave been characterized along with a number of natural products of microbial, plant and marine origin. Amongthese are tyrphostins9), erbstatm10), genistein1 1^ and halenaquinone12). Weconducted a high th...
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One of the most applied methods in drug industry for development of new drugs is 3D-QSAR methodology. As p38-mitogen-activated protein kinase (p38-MAPK) plays a crucial role in regulating the production of such proinflammatory cytokines as tumor necrosis factor-α (TNF-α) and interleukin-1, emerging as an attractive target for new anti-inflammatory agents, we used a 3D-QSAR based method of Compa...
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Aspartic proteases are relatively a small group of proteolytic enzymes. Over the last decade, they have received tremendous research interest as potential targets for pharmaceutical intervention as many have been shown to play significant roles in physiological and pathological processes. Despite numerous efforts, however, the only inhibitors for aspartic proteases currently in the market are d...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1997
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.110.supplement_81